Paliperidone Impurity 30

Paliperidone Impurity 30 - Names and Identifiers

Name	2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride
Synonyms	NH26248 138271-16-6 Paliperidone Impurity 30 (2, 4-dp)-piperidin-4-yl-methanone oximehcl (2,4-DIFLUOROPHENYL)(PIPERIDIN-4-YL)METHANONE OXIME HCL (2,4-Difluorophenyl)-4-piperidylMethanone OxiMe Hydrochloride 2,4-DIFLUOROPHENYL-(4-PIPERIDINYL)METHANONE OXIME HYDROCHLORIDE 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride (2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride (Z)-(2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride (Z)-(2,4-Difluorophenyl)piperidin-4-ylmethanone oxime monohydrochloride (E)-1-(2,4-difluorophenyl)-N-hydroxy-1-piperidin-4-ylmethanimine hydrochloride
CAS	135634-18-3
EINECS	603-927-4
InChI	InChI=1/C12H14F2N2O.ClH/c13-9-1-2-10(11(14)7-9)12(16-17)8-3-5-15-6-4-8;/h1-2,7-8,15,17H,3-6H2;1H/b16-12+

Paliperidone Impurity 30 - Physico-chemical Properties

Molecular Formula	C12H15ClF2N2O
Molar Mass	276.71
Boling Point	383.2°C at 760 mmHg
Flash Point	185.6°C
Vapor Presure	1.48E-06mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

Paliperidone Impurity 30 - Introduction

(2,4-Difluorophenyl)-(4-piperidinyl) methanone oxime hydrochloride, the chemical formula is C12H9F2N2O · HCl. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
(2,4-Difluorophenyl)-(4-piperidinyl) methanone oxime hydrochloride is a white crystalline powder with good solubility, soluble in polar solvents such as alcohol and DMF (dimethylformamide), slightly soluble in water. It is a weakly basic compound that can react with acids to form hydrochloride salts.

Use:
This compound is often used in some important reactions in organic synthesis, such as heterocyclization reactions and C- C bond formation reactions. It has important applications in drug synthesis and can be used to prepare a variety of biologically active compounds.

Preparation Method:
The preparation method of (2,4-difluorophenyl)-(4-piperidinyl) methanone oxime hydrochloride is as follows:
(2,4-Difluorophenyl)-(4-piperidinyl) methanone was first dissolved in hydrochloric acid, and then the reaction was stirred at room temperature to produce a white precipitate. The precipitate is washed, filtered and dried to give the pure product.

Safety Information:
This compound is a chemical and must be used under strictly controlled laboratory conditions. It may cause irritation and damage to the eyes, skin and respiratory tract, so it is necessary to wear appropriate protective equipment, such as laboratory gloves, safety glasses and protective masks. At the same time, avoid inhaling its dust or solution, and maintain good ventilation. If taken by mistake or inhaled by mistake, seek medical attention immediately.

Last Update：2024-04-09 21:11:58